Rejection & Autoimmunity
Complement component 3, or C3, is a protein of the immune system that plays a central role in the complement system and contributes to innate immunity. Its activation is required for both classical and alternative complement activation pathways.
Product Code Product Name BSB 6391 C3d, 0.5 ml, concentrate BSB 6388 Tinto C3d, 7 ml, predilute BSB 6392 C3d, 1 ml, concentrate BSB 6389 Tinto C3d, 15 ml, predilute
- C4dComplement component 4, or C4, plays a central role in the complement system. C4d is the final proteolytic remnant of deposited C4b on endothelium and remains covalently attached to endothelium for little more than a week.
Product Code Product Name BSB 6398 C4d, 0.5 ml, concentrate BSB 6395 Tinto C4d, 7 ml, predilute BSB 6399 C4d, 1 ml, concentrate BSB 6396 Tinto C4d, 15 ml, predilute
- iNOSNitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
The inducible isoform iNOS produces large amounts of NO as a defense mechanism. It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack by parasites, bacterial infection, and tumor growth.
Product Code Product Name BSB 2660 iNOS, 0.5mL, Concentrate BSB 2657 Tinto iNOS, 7mL, Predilute BSB 2661 iNOS, 1mL, Concentrate BSB 2658 Tinto iNOS, 15mL, Predilute